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When considering the combination of these medications, several factors should be taken into account: Overlapping side effects Both medications can cause gastrointestinal symptoms, which may be additive when used together

The direct action of GLP-1 which can also be demonstrated in the perfused pancreas, with isolated islets and with beta cell derived cell lines involves activation of the beta cell GLP-1R which couples through the heterotrimeric G-protein Gs to activate adenylyl cyclase and increase intracellular cAMP (27, 65)