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In a cohort of 74 patients with biopsy-proven NASH, 48-week treatment with rosiglitazone combined with diet and physical activity, compared to diet and exercise alone, was shown to significantly ameliorate NAS, steatosis, and ballooning, but no effect was detected on fibrosis [45]

This is the observation phase

[PowerPoint Presentation] [13] FDA, UPDATED MEETING, supra note 4

doi: 10.1021/bi901180v

Patients who take this route should consult with their doctors about post-GLP-1 weight management strategies

The first 612 weeks after stopping typically show the most stability, as the medication remains partially active and behavioral changes haven't fully reversed