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The goal is to distinguish between self-limited causes and conditions that need specific therapy

Younger children have higher growth velocities, are more likely to be prepubertal, and have developing hypothalamic-pituitary-gonadal axes

Immunol Rev 273:357370 Grinberg N, Elazar S, Rosenshine I, Shpigel NY (2008) -Hydroxybutyrate abrogates formation of bovine Neutrophil extracellular traps and bactericidal activity against mammary pathogenic Escherichia Coli

It is downregulated in gastric and colorectal cancers but upregulated in lung adenocarcinoma and breast tumors compared to normal tissue (Liu et al., 2017