Science 368 (6487), eaaw5473
The goal is to understand why inflammatory signaling is elevated and whether modifiable drivers are present: visceral fat, periodontal disease, poor sleep, alcohol, insulin resistance, autoimmune activity, environmental exposure, chronic infection, or unresolved cardiometabolic risk
Losing weight too quickly without adequate protein intake and appropriate resistance exercise can lead to loss of lean muscle mass
Bonus: It sits beautifully under makeup, with zero pilling
Current evidence does not support using B12 as a weight loss intervention, and B12 products have no licensed indication for weight loss in the UK
Supernatants were removed and treatments were stopped by the addition of 50 L lysis buffer containing PhosSTOP and Complete (Roche Diagnostics, Mannheim, Germany)