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doi: 10.1111/j.2042-3306.1995.tb04969.x 24 GassmannMLutzTAKaspersBGbelT

Taking the dose after this timeframe could result in receiving two doses too close together, potentially increasing the risk of gastrointestinal adverse effects such as severe nausea, vomiting, or abdominal discomfort

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Wu et al., 2011

Estos efectos ocurren principalmente en el tracto gastrointestinal

However, recently, a superior effect of triple agonists has been indicated, with triple agonists providing a greater neuroprotective benefit against glutamate excitotoxicity compared with dual receptor agonists [126]