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The peptide exists as a copper chelate with high affinity for Cu(II) ions

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Key sources of heterogeneity include variations in acupoint selectionwith some studies using fixed classical acupoints (e.g., ST36, LR3, CV12) while others employ individualized point selection based on Traditional Chinese Medicine pattern differentiation (82)and in stimulation parameters, where electroacupuncture frequency ranges from 2 to 100 Hz with variable pulse widths, intensities, and treatment durations (ranging from 20 to 45 min per session) (23, 44)

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