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How is safety designed, monitored and reviewed during a First-in-Human trial

The phosphorylation of a conserved tyrosine residue (Tyr694 in STAT5A and Tyr699 in STAT5B) within the C-terminal transactivation domain is a pivotal post-translational modification required for STAT5 activation

Rolfs A, Montor WR, Yoon SS, Hu Y (2008) Production and sequence validation of a complete full length ORF collection for the pathogenic bacterium Vibrio cholerae

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In preclinical models its reported effects concentrate at or near the site of administration, where it appears to promote new vessel formation, support fibroblast activity and stabilise the local healing environment