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SUSTAIN 6 Trial In this trial, new or worsening nephropathy, defined as persistent macroalbuminuria, persistent doubling of the serum creatinine, or a creatinine clearance 339 mg/mmol), a sustained decline in eGFR of 30% or more from baseline, or chronic renal replacement therapy (322)

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Long-term storage: Refrigeration at 4 C (39 F) extends shelf stability

How does the dosage change with semaglutide

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That means changing only one variable, like cooling after injection, can help some people but not others