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It is associated with insulin resistance as seen in type 2 diabetes mellitus

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Herz: So as I was saying, the evolution of what were finding out about these drugs, what they can do, it seems pretty remarkable

Circular dichroism spectroscopy, which we did to understand the secondary structure of our best candidate bovine IF, which indicated a predominantly helical secondary structure consistent with native folding, while computational docking predicted bovine and human IF to have optimal geometric complementarity and stabilising energies with B12, in agreement with our experimental binding data

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