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Frequency: one subcutaneous injection each day (or a 5-on / 2-off schedule), over an 812 week cycle

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The paucity of in vivo studies pertaining to the immunogenicity of nanoparticles, cumulative dosing, biodistribution, and interactions between bone and the tumor microenvironment contributes to a limited understanding of the mechanism(s) of action of nanoparticles in primary and secondary tumor sitesespecially considering that factors such as moisture sensitivity and the rapid conversion of calcium oxide to calcium hydroxide can introduce challenges for systemic administration 104

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