Hydroxocobalamin has an excellent safety profile, as excess B12 is readily excreted in urine
In type 2 diabetes mellitus, portal vein insulin levels are elevated to compensate for the insulin-resistant state of the body
Sometimes, however, a drugs dose can be so variable that the manufacturer provides a sufficient quantity in the single-use vial to accommodate a wide range of amounts
While substantial, it is far lower than the risk attributed to diabetes (HR 10.7) or metabolic syndrome (HR 6.1), and slightly lower than elevated blood pressure (HR 4.6)
"Novo Nordisk stands behind the safety and efficacy of our FDA-approved semaglutide medicines when used as indicated and when taken under the care of a licensed healthcare professional." The company also said it cannot "validate the safety or effectiveness of compounded products" with semaglutide that are not Novo Nordisk-branded products
Visible degradation signs include color changes (yellowing), cloudiness in reconstituted solution, particulate matter, or visible precipitation