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Once in circulation, GLP-1 has a short half-life (1 to 2 minutes) due to rapid degradation by the ubiquitous endogenous enzyme dipeptidyl peptidase-4 (DPP-4)

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GLP-1 drugs, such as Ozempic and Mounjaro, are approved for the treatment of Type 2 diabetes and can be an important tool in treating diabetic members