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Since our proteomic study suggested mitochondrial alterations following HC treatment, and considering the recent hypothesis of Simeone (Simeone, 2025) that HC might interact with key cellular antioxidant systems, mitochondrial function was further investigated through oxygen consumption rate (OCR), extracellular acidification rate (ECAR), mitochondrial membrane potential, mitochondrial network morphology, ROS production and GSH/GSSG ratio

the 2025 Larsen Circulation: Arrhythmia & Electrophysiology finding that ~31% of highly symptomatic Long COVID patients meet PoTS criteria

The authors concluded that TB4 is a multifunctional regenerative peptide important in dermal repair, acting through promotion of cell migration, stem cell mobilisation and differentiation, and inhibition of inflammation and apoptosis

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