however, no significant resolution was observed
Insulin resistance and inflammatory markers, both linked to obesity, appear to reduce sperm motility, the ability of sperm to swim, and increase sperm DNA fragmentation, a form of genetic damage within sperm cells
The reason I say that is not because of the efficacy data, because the efficacy was pretty similar across both trials
Clinical Relevance: Supports mechanism of centrally-mediated satiety enhancement rather than conditioned taste aversion
Wu, G.D
The checkpoint inhibitor agents included in the study were CTLA-4 inhibitors, PD-1 inhibitors, PD-L1 inhibitors, and combination treatment with a CTLA-4 inhibitor (ipilimumab) and a PD-1 inhibitor (nivolumab)