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Novel studies found that GLP-1RAs such as liraglutide, semaglutide and exendin-4 reduces -synuclein aggregation respectively in MPTP (a mitochondrial complex I inhibitor) and 6-OHDA induced PD mice models as well as rat model of -synucleinopathy

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In the hyperglycemic state, AR depletes NADPH while increasing the accumulation of F6P, so there is a close influence between several glucose metabolic pathways

Iron and 4HNE levels in the spleen and liver tissues are stained with Prussian blue staining (#IW-3010, IHC world) and immunohistochemistry (IHC) staining

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