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Common side effects may include nausea, upset stomach, diarrhea, or constipation

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In the -cell, PC1/3 is up-regulated, resulting in increased processing of proglucagon to GLP-1 while DPP-4 is down-regulated in order to reduce degradation and enhance local intact GLP-1 concentrations

Venezuela maritza.diaz @ cnic.edu.cu Comment of the reviewer Angel San Miguel, MD