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The insulin resistance in PCOS might also occur independently of body weight, due to inherited post-receptor defects in insulin signalling that affects metabolism and mitotic pathways, not only in classic insulin target tissues, such as skeletal muscle, liver, and adipose tissue, but also in the non-classical target tissues, such as pituitary and ovary [12, 16]
Biological sample preparation L-glutathione in oxidised (GSSG) and reduced (GSH) state was purchased from Sigma Aldrich (#G4376 and #G4251, respectively) and dissolved in distilled water with a concentration of 10 mg/ml
Semaglutide works by mimicking a hormone called glucagon-like peptide-1 (GLP-1), which regulates appetite and food intake
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