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In the above studies, patients only experienced sustained weight loss by pairing these medications with dietary and exercise changes

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PMCID: PMC8351017

Due to findings of thyroid C-cell tumours in rodent studies, patients with a personal or family history of medullary thyroid carcinoma (MTC) or those with multiple endocrine neoplasia syndrome type 2 (MEN 2) should be carefully evaluated regarding the benefit-risk balance of using semaglutide

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It should be used with caution in patients with medical conditions that may affect kidney function