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Many GPCRs, including GLP-1R and GIPR, couple to the stimulatory G protein, Gs, to activate adenylyl cyclase and produce the second messenger cyclic AMP

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In particular, the PI3K/AKT axis converts phosphatidylinositol-4,5-bisphosphate (PIP 2 ) to phosphatidylinositol 3,4,5-trisphosphate (PIP 3 )