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The prevailing theory suggests that migraine is a neurovascular disorder initiated within the central nervous system (CNS), characterized by an increased sensitivity of the trigeminovascular system (TVS) leading to pain

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The expression of ATP-binding cassette subfamily B member 7 and mitochondrial oxidative phosphorylation enzymes were significantly downregulated in rats with left ventricular hypertrophy, while lipid metabolites, iron, ROS, and autophagy-associated proteins were upregulated in the cytoplasm and mitochondria

Ardestani, A., Lupse, B., Kido, Y., Leibowitz, G