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Reduction of pancreatic -cell dedifferentiation after gastric bypass surgery in diabetic rats

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423 The research further demonstrated that this anti-inflammatory effect was not mediated by GLP-1R in the blood or endothelial cells but required the GLP-1R in the CNS

Trial protocols use a stepwise titration starting at 2 mg weekly

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Efficacy and safety of canagliflozin as add-on therapy to a glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes mellitus: A 52-week, open-label, phase IV study