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Connexin 43 in astrocytes helps maintain the BBB, and its loss causes continuous immune cell recruitment (69).Pericytes ensure endothelial integrity, regulating astrocytic endfeet, leukocyte trafficking, and vascular immune homeostasis and vasomotor (69, 70)

Still in trials: Orforglipron is not yet FDA-approved

This may allow it to expand beyond endocrine clinics, although education and training will still be important

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These drugs are prescribed by doctors and have a powerful effect

Study details, background and design: The prospective cohort study included 63,656 adults with Type 2 diabetes within the Million Veteran Program with no previous history of heart attack, stroke, cancers or advanced chronic kidney disease