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Physiol Rev 2016;96:11691209 [DOI] [PubMed] [Google Scholar] 134

[] FOCUS TRIAL The ongoing FOCUS trial is a 5-year study aimed at assessing the long-term effects of semaglutide on DR in people with T2D, expected to complete by 2027

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The ligands of the manganese ions are 3 histidine side-chains, an aspartate side-chain and a water molecule or hydroxy ligand, depending on the Mn oxidation state (respectively II and III)