Semaglutide improved cognitive regression in this model of tauopathy through microglial T-polarization mediated by autophagy/ACE2/SIRT1/FOXO1 signaling pathways
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We determined cell viability and cytotoxicity by using tetrazolium reduction assay and Lactate Dehydrogenase (LDH) assay, performed real-time PCR and protein quantification to assess the expression of biomarkers after treating cells with copper peptide (GHK-Cu), copper chloride (CuCl 2 ) and copper acetate (Cu(OAc) 2 )
Thus, the C347K/R mutation lowers the energy barrier of GLP-1R to be activated by its ECD and this lower energy barrier can be overcome by a weak interaction of the non-specific five residue linker, which in this case serves as a positive allosteric modulator for the mutated receptor
