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These established therapies should generally be considered first-line treatments unless contraindicated or ineffective for individual patients

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Whereas restless leg syndrome is associated with both an iron deficiency in the brain for genetically susceptible individuals and dopaminergic system dysfunction, potentially involving a presynaptic hyperdopaminergic state, in other patient populations

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This characteristic makes cardiac glycosides good candidates as senolytics to target senescent cells, due to their role as specific inhibitors of the NA + /K + ATPase pump

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