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In another study, Hiraoka et al

doi: 10.3390/biom11040555

Available evidence comes primarily from observational reports and mechanistic studies rather than large randomized controlled trials, so provider clinical judgment remains central to decision-making

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Weeks 612: Stabilization Phase Between two and three months, benefits often become more consistent: Hot flashes significantly reduced or resolved Improved daytime energy Better sleep efficiency More predictable symptom control This is also the window where dose adjustments may be considered if symptoms persist or side effects emerge