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Fewer patients had impaired glucose tolerance and saw their cholesterol profiles improve Trial #6 was the nail in the coffin: The group taking AOD-9604 and the group taking the placebo were also following a strict diet and exercise routine over the entire 24-week period yet the weight loss induced in the AOD-9604 group was not statistically significant (at least not compared to HGH)

Novo Nordisk press release OASIS 4 results (September 2025) 11

Appetite suppression strong signals of fullness reduce the desire to eat

Retatrutide is unique among current weight loss medications in targeting the glucagon receptor, which promotes thermogenesis and fat oxidation

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