Insulin waning refers to a progressive increase in blood glucose levels from bedtime to morning
The medication class has transformed weight management because it addresses the biological drivers of weight gain rather than simply restricting calories through willpower
Duration varies from patient to patient
The pyridoxine in the compound formulation does not typically increase injection site discomfort, though some users report a mild warming sensation at the injection site that resolves within minutes
Key takeaways Sleep disruption during perimenopause affects up to 60% of women and has clear hormonal causes it's not just stress or ageing Declining oestrogen reduces melatonin production, while falling progesterone lowers GABA activity both directly affect your ability to fall and stay asleep The common 3am wake-up is often caused by an early cortisol surge, compounded by night sweats and circadian rhythm changes Your gut produces 95% of your body's serotonin (a precursor to melatonin), making gut health an overlooked route to better sleep Evidence-based strategies that help include: morning light exposure, magnesium-rich nutrition, regular movement, targeted supplements, HRT and CBT-I In this article How perimenopause affects sleep Common perimenopause sleep symptoms What actually helps: evidence-based strategies When to see your GP The bottom line How perimenopause affects sleep Sleep problems during perimenopause aren't caused by one thing
If you start at a lower dose and take your supplement with food, most people never experience them at all
