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Participants received weekly subcutaneous injections of Retatrutide Powder at doses ranging from 1 mg to 12 mg for approximately 48 weeks

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Structural Modification 1: Amyloid-Resistant Scaffold Substitutions at Residues 20-29 The aggregation-prone segment of native amylin (residues 20-29) was redesigned in cagrilintide through targeted amino acid substitutions

The STEP-HFpEF DM trial investigated whether the changes in glucose levels in HFpEF patients with obesity moderates the treatment benefits of GLP-1 RAs

Typically administered via subcutaneous injections, with doses ranging from 100-300 mcg

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