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Vitamin C is often preferred by people who want to support skin radiance and collagen production

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Because bulk cytosolic readouts obscure compartmental signals, measurement should rely on ER-targeted genetically encoded H 2 O 2 probes (e.g., roGFP-Orp1 or HyPer-ER), which report local peroxidatic events without cytosolic averaging and allow discrimination of ER-confined redox dynamics from extra-ER sources (Rashdan and Pattillo 2020