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Overview of Mechanistic Crosstalk in PD Pathogenesis PD is caused by a number of disease-specific stressors, including aggregation of -synuclein, dopamine oxidation products, mitochondrial dysfunction, and exposure to environmental neurotoxins such as rotenone and MPTP

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LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the KruskalWallis test used alone can achieve a lower false-negative rate compared to LEfSe 38