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GLP-1 RAs reduce cardiovascular risks but may cause nausea and GI issues

In addition, the activation of GLP-1R results in a cascade that activates adenyl cyclase via G s , resulting in an increased secretion of cyclic adenosine monophosphate (cAMP) secretion and activating cAMP-dependent protein kinase (PKA)

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This section is divided into three parts: probes aiming for (1) tracking lipid biosynthesis (Section 4.2.1), (2) studying lipidation as protein posttranslational modifications (Section 4.2.2), and (3) assessing lipid catabolism (Section 4.2.3)

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Clinical outcomes with GLP-1 receptor agonists in patients with heart failure: a systematic review and meta-analysis of randomized controlled trials