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2021;14:E538 ( Epub 2021 Jul 1 )

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Importantly, combination of metformin and radiation significantly increased cell death, when compared to irradiated vehicle controls, highlighting the potential role for altered cell death in the metformin-mediated radiosensitisation of these cell lines

The peptide works through several mechanisms: it upregulates growth factor expression (particularly VEGF), promotes angiogenesis (the formation of new blood vessels at injury sites) [5,12] , modulates the nitric oxide system, and supports the FAK-paxillin pathway, which governs cell migration to damaged tissue

Potential offlabel or alternative uses discussed in medical settings can include appetite control during weight regain risk periods, or metabolic support in people with insulin resistance, but these uses depend on local regulations and individual medical assessment