Ozempic is also approved to prevent worsening kidney function and heart-related death in people who also have chronic kidney disease (CKD)
Retatrutide is an investigational triple agonist activating GLP-1, GIP, and glucagon receptors simultaneously, producing greater weight reduction than single or dual agonists
These resources recommend that clinicians consider B12 deficiency in any patient presenting with relevant symptoms or risk factors, and that treatment particularly intramuscular hydroxocobalamin should not be delayed pending specialist review when deficiency is confirmed and symptomatic, especially where neurological involvement is present
Patients often experience fewer side effects compared to older medications, making it a compelling option for long-term management
Cautions include history of pancreatitis, gallbladder disease, and diabetic retinopathy (particularly with semaglutide)
How Long Reconstituted Retatrutide Remains Stable There is no approved SmPC or regulatory-validated in-use shelf life for reconstituted retatrutide