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Another phase 1 and 2 trial was completed in Egypt to examine the effect of combining melatonin with whole-body cooling on brain injury and the outcome of neonates following perinatal asphyxia (NCT02071160)

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Notably, all participants started with very high ICP (mean ~ 30.6 cmCSF), so a 56 cmCSF reduction was felt to be clinically meaningful (roughly 1520% reduction)

Always consult a licensed healthcare provider before medications or treatment plans

Sterile Water for Injection is exactly what it sounds like: highly purified, sterile water with no additives

LC-MS analysis of urine samples Samples were prepared based on the methodology proposed by Spagou et al