People with a family or personal history of medullary thyroid cancer Those diagnosed with multiple endocrine neoplasia type 2 Patients dealing with ongoing pancreatitis or unexplained stomach pain Women who are pregnant or nursing Anyone with serious digestive issues like gastroparesis How TrimBody M.D
What the Evidence Supports: Ingredient-level research on strains like Akkermansia muciniphila shows associations with improved metabolic markers in some studies
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I think that whats becoming apparent with the GLP-1s, with respect to medical applications, is theyve got pretty broad reach, he says
The cardiovascular benefits of GLP-1-RAs arise primarily through indirect systemic mechanisms, with limited evidence supporting direct effects on cardiomyocytes ( Figure 1 )
But he lacked the appropriate tools to prove it (Unger)