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What to Expect in the First Few Weeks of Treatment The first few weeks are characterised primarily by gastrointestinal adjustment including nausea, reduced appetite, and diarrhoea rather than dramatic weight loss, with appetite reduction often noticeable within one to two weeks

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It should be emphasized that the addition of any antihyperglycemic agent to a patients current insulin therapy has the potential to increase the risk of insulin-induced hypoglycemia, particularly at the start of therapy

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