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It can also take 6 to 12 hours before the alcohol fully clears out of your bloodstream (hello, hangover!) According to the National Institute on Alcohol Abuse and Alcoholism, factors that affect how quickly or how long alcohols effects take to wear off include: what you drink eating or sipping water while drinking drinking on an empty stomach how much you drink how fast you drink (drinking more than one drink per hour) your sex or overall size As you probably expected, how much and what you drink can really affect how long you feel tanked

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