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Dropping the 1mg arm acknowledges that while it produced statistically significant weight loss, the magnitude was insufficient for a competitive regulatory filing

Consider B-complex for energy, vitamin D if deficient, and omega-3 for heart health

Proposed mechanisms include indirect effects via weight loss and reduced inflammation, though no direct electrophysiological action on atrial tissue has been established

Fatigue during tirzepatide treatment may relate to caloric restriction from appetite suppression rather than a direct drug effect

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