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Recent studies show that exposure to GLP1-RA in the first trimester is not associated with a risk of major birth defects when compared with diabetes or obesity

Metformin targets mitochondrial electron transport to reduce air-pollution-induced thrombosis

It communicates with your brain to reduce appetite, tells your liver to slow glucose production, and slows gastric emptying so you feel full longer

This lends further weight to prospective investigation of the benefits and safety of GLP-1 RAs in the real world which are resumed in Table 2

It mimics the hormone GLP-1, which helps regulate blood sugar and appetite

However, for patients who have already reached a healthy weight, microdosing may help maintain results while potentially providing ongoing metabolic benefits with fewer side effects