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Symptoms following acute NSAID overdose are usually limited to lethargy, drowsiness, nausea, vomiting and epigastric pain, gastrointestinal bleeding can occur but very rarely, hypertension, acute renal failure, respiratory depression and coma

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Surgical intervention, particularly for necrotising pancreatitis, further increases diabetes risk

The meta-analysis of the randomized trials of folate supplementation also supports this conclusion

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