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Subcutaneous injections exceeding 0.5mL per site reduce absorption efficiency due to depot formation

doi: 10.1177/1060028019889064 104 Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults with overweight or obesity without diabetes: The STEP 8 randomized clinical trial

The primary risk is reduced therapeutic effect, meaning you may not experience the appetite suppression or metabolic benefits you need for weight loss

The velocity, depth, and dwell time were set (see Supplementary Table S1) and the impact was performed, with the tip making contact around the site of bregma

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