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developed a personalized joint-on-a-chip platform that integrates human chondrocytes and FLS isolated from OA patients into a compartmentalized microfluidic device ( 7.4 Autologous vascular compartment: a challenge toward immunocompetent aOoC systems Significant progress has been made in developing sophisticated OoC platforms for joint pathology, yet a fundamental physiological component remains insufficiently represented: the vascular network

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At low concentrations (0.01 nM), MMP1 and MMP2 gene expression increases, facilitating removal of damaged ECM proteins

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