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Peer review Peer review information Nature thanks Lucas Sullivan and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Structural optimization: Further reduce IGFBP binding ability through site directed mutagenesis, or introduce transmembrane peptides to enhance tissue penetration

Competition for glutathione precursors between the immune system and the skeletal muscle: pathogenesis of chronic fatigue syndrome. Medical hypotheses 53.4 (1999): 347-349

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Currently, however, its exact roles in disease development and prevention remain unclear

Abbreviations : NET, norepinephrine transporter