The Endocrine Society research showed that men who lost 10% of body weight with GLP-1 medications saw their normal testosterone proportion rise from 53% to 77%, without any testosterone supplementation
One important factor may be that GLP-1 receptor agonists can cause delayed stomach emptying, which helps keep you full longer, increases satiety, and suppresses your appetite (Muller, 2019)
229,230,231,232,233 SIRT5-mediated desuccinylation also participates in protection against peroxisome-induced oxidative stress via targeting ACOX1
Amplification effects
A nice talk with a professional should feel simple, not fast
These medications may still be covered for their FDA-approved diabetes indications, but using them off-label for weight management is increasingly difficult to get approved