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Glycemic Control in Type 2 Diabetes: The SURPASS Clinical Trial Program The SURPASS program comprised a series of global registration trials designed to evaluate the efficacy and safety of Tirzepatide across the entire continuum of T2D care, from initial monotherapy in treatment-nave individuals to add-on therapy in patients with long-standing, difficult-to-control disease, including those already on insulin

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Whether this interaction is clinically meaningful in humans at therapeutic semaglutide doses is an open question, but it represents a direct neurological pathway worth investigating

This means that for many of our patients, medical weight loss is not cosmetic

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