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We identified the top 20 up- and downregulated genes in fibroblasts from semaglutide-treated hearts, confirming the consistency of these changes across different fibroblast subclusters

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In particular, increased activity of AChE and MAO was detected in fructose-fed rats

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Treatment starts with 0.25 mg once weekly for 4 weeks as an initiation dose (not for glycaemic control), then increases to 0.5 mg once weekly