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01:00:10 - The Three GLP-1 Use Cases for Practitioners Sarah outlines the three main practitioner applications

The most frequently reported issues include: Nausea : 21.49% of patients Diarrhea : 10.62% Vomiting : 9.10% Dyspepsia (indigestion) : 8.67% Constipation : 7.92% Decreased appetite : 5.49% While many tolerate these medications well, over 10% of patients stop or interrupt treatment due to severe discomfort

All clinical trial protocols used once-weekly subcutaneous injection

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Phase 3 monotherapy available Feature Expected GI burden Cagrilintide + Retatrutide Very high CagriSema (Cag + Sema) High Retatrutide Alone High Feature Dysesthesia risk Cagrilintide + Retatrutide Yes (retatrutide component) CagriSema (Cag + Sema) No Retatrutide Alone Yes Feature Injections per week Cagrilintide + Retatrutide 2 (separate) or 1 (pre-blend) CagriSema (Cag + Sema) 1 or 2 Retatrutide Alone 1 Feature Regulatory status Cagrilintide + Retatrutide Neither approved

Rapid weight loss associated with retatrutide may indirectly alter skin barrier function, causing dryness or heightened sensitivity