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Additionally, pramlintide has been approved as adjunct to insulin therapy for treatment of type 1 and type 2 diabetes due to its ability to regulate post-prandial glucose levels, reduce body weight, and HbA1c [34, 37, 42]

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While semaglutide pharmacokinetics are not significantly altered in patients with hepatic impairment, the medication has not been extensively studied in patients with severe hepatic dysfunction

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