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The 10 nm Au NPs had the most extensive organ distribution including blood, liver, spleen, kidney, testis, thymus, heart, lung, and brain, while the larger NPs were only found in blood, liver, and spleen

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Indirect effects The hypoxia-induced acidic microenvironment of tumors can affect drug efficacy 45 , and promote the phenotypic expression of breast cancer stem cells (CSCs) and the acquisition of MDR in breast cancer

Jeong S-H, Jang J-H, Cho H-Y, Lee Y-B (2020) Risk assessment for humans using physiologically based pharmacokinetic model of diethyl phthalate and its major metabolite, monoethyl phthalate

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